Laboratory of Bioinorganic Immunology & Drug Discovery

We are a dynamic and multinational team working in the Institute of Pharmaceutical Sciences at King's College London

Research

Our multidisciplinary research crosses the boundaries of bioinorganic chemistry and immunology/virology. We use a combination of molecular biology and cell biological methods, biophysical techniques, biochemical assays, and computational biochemistry.

The research in our group is broadly divided into two themes: (i) Protein engineering to design and develop new therapeutics and (ii) Elucidating the function of iron-sulfur clusters, one of the oldest bioinorganic cofactors of life, at the crossroads of the immune response and cancer.

News & Events

A-ProX, a spinout based on the group discoveries and supported by King's Spinout Accelerator Program

MRC Gap Fund to Design and Develop Novel Multifunctional Antivirals.

M.Sc. Student Theo Situmorag Wins Best Thesis Prize

PhD student Thao Nghi Hoang's Review Article Published in Current Opinion in Chemical Biology

PhD Student Yujie Sheng Wins Best Poster Prize in COST Yong Investigator Meeting, TU Delft, the Netherlands

Latest Publications

A Versatile Virus-Mimetic Engineering Approach for Concurrent Protein Nanocage Surface-Functionalization and Cargo Encapsulation

We mimic the HIV-1 Gag polypeptide precursors and create precursors of nanocages (PRECs). We show that in the presence of a protease, the precursors are cleaved to form subunits that are spontaneously self-assembled to generate PINCs (Protein-induced nanocages). The PINC formation is used to encapsulate a cargo and concurrently decorate the nanocages’ surface with a protein.